Rachel E. Andrews, Deni S. Galileo, Patricia A. PMCA4's partners in sperm and how its absence exerts its effect on fertility are unknown. We show that in human sperm PMCA4 is present on the acrosome, inner acrosomal membrane, posterior head, neck, midpiece and the proximal principal piece. Finally, flow cytometry demonstrated that following co-incubation of sperm and seminal plasma, PMCA4 and the NOSs can be delivered in vitro to sperm via prostasomes. Our studies point to the potential underlying cause of infertility in PMCA4's absence, and suggest that inactivating mutations of PMCA4 could lead to asthenozoospermia and human infertility. Screening for these mutations may serve both diagnostic and therapeutic purposes. Calcium extrusion from the cytosol, like its influx, is essential for maintaining normal sperm motility and fertility, yet little is known of the mechanisms involved in human sperm.
Movie & TV News
You know his name. You got his number. The non-comic caper is the worst-reviewed James Bond movie, and was produced outside of franchise gatekeepers Eon. Three of his movies are Rotten, three are Fresh, and one is Certified Fresh. Not bad, and he even traveled into space. Pierce Brosnan brought back the sophisticated sex appeal, as the best Bond in the not-so-greatest movies. After Austin Powers took the piss out of the franchise for a decade, Eon turned to resurrecting James Bond as the brooding, brutish hulk we have today. At 15 years, Craig holds the record for longest uninterrupted ownership of Bond, but Connery spread his appearances as Bond across 21 years. Synopsis: Director John Glen tries his damnedest -- a pre-credit snowmobile chase, a parachute jump off the Eiffel Tower, a life-or-death
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My life is so hard, innit? I have very specific tastes in oatmeal raisin cookies. A crisp edge is always welcome, but the rest of it must be thick and chewy.
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